一、基本信息

姓名：鄢和新

职称：研究员

联系邮箱：hexinyw@163.com

二、学习经历

1992.8 –1996.7， 第三军医大学，实验诊断学，学士

1999.8 –2004.7， 第二军医大学，生物化学与分子生物学，博士，

2010.5 –2012.8， 美国南加州大学干细胞与再生医学中心，博士后

三、拟招收博士后开展的研究方向

1、肝再生中的细胞命运调控；

2、肝病的细胞治疗。

四、主要学术任职

1、Cell Research 审稿人

2、Cancer Letters 审稿人

3、Stem Cells 审稿人

4、中国整形美容协会干细胞研究与应用分会，常务理事

五、主要获奖情况

1、鄢和新（第二完成人），恶性肿瘤磷酸化调控的信号转导研究，国家科技部，国家自然科学奖，二等奖， 2007

2、鄢和新（第二完成人），肿瘤相关信号调节蛋白的功能研究，上海市医学会，上海市医学科技奖，一等奖，2008

文，董立巍，付静，董辉，吴孟超）

3、鄢和新（第三完成人），肝脏炎-癌转化机理的新发现及科学意义，上海市科学技术奖励委员会，上海市自然科学奖，一等奖，2014

4、上海市东方学者特聘教授，2012

5、上海市浦江人才，2013

6、上海市优秀学术带头人，2016

7、上海市卫生系统优秀学科带头人，2018

六、代表性论文

1.Fu GB, Huang WJ, Zeng M, Zhou X, Wu HP, Liu CC, Wu H, Weng J, Zhang HD, Cai YC, Ashton C, Ding M, Tang D, Zhang BH, Gao Y, Yu WF, Zhai B, He ZY, Wang HY, Yan HX(*). Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens. Cell Res. 2018 Oct 25. doi: 10.1038/s41422-018-0103-x.（17.8）

2.Qin CJ, Zhao LH, Zhou X, Zhang HL, Wen W, Tang L, Zeng M, Wang MD, Fu GB, Huang S, Huang WJ, Yang Y, Bao ZJ, Zhou WP, Wang HY, Yan HX (*). Inhibition of dipeptidyl peptidase IV prevents high fat diet-induced liver cancer angiogenesis by downregulating chemokine ligand 2. Cancer Lett. 2018 Apr 28;420:26-37. （6.5）

3.Wu H, Zhou X, Fu GB, He ZY, Wu HP, You P, Ashton C, Wang X, Wang HY, Yan HX (*). Reversible transition between hepatocytes and liver progenitors for in vitro hepatocyte expansion. Cell Res. 2017 May;27(5):709-712.（17.8）

4.Zhang HL, Wang MD, Zhou X, Qin CJ, Fu GB, Tang L, Wu H, Huang S, Zhao LH, Zeng M, Liu J, Cao D, Guo LN, Wang HY, Yan HX (*), Liu J. Blocking preferential glucose uptake sensitizes liver tumor-initiating cells to glucose restriction and sorafenib treatment. Cancer Lett. 2017 Mar 1;388:1-11. （6.5）

5.Liu Q, Wen W, Tang L, Qin CJ, Lin Y, Zhang HL, Wu H, Ashton C, Wu HP, Ding J, Dong W, Yu LX, Yang W, Huang DD, Wu MC, Wang HY, Yan HX(*). Inhibition of SIRPα in dendritic cells potentiates potent antitumor immunity. Oncoimmunology. 2016 Aug 23;5(9):e1183850.（5.3）

6.Wang MD, Wu H, Huang S, Zhang HL, Qin CJ, Zhao LH, Fu GB, Zhou X, Wang XM, Tang L, Wen W, Yang W, Tang SH, Cao D, Guo LN, Zeng M, Wu MC,Yan HX (co-corresponding author), Wang HY. HBx regulates fatty acid oxidation to promote hepatocellular carcinoma survival during metabolic stress. Oncotarget.2016 Feb 9;7(6):6711-26.

7.Wang MD, Wu H, Fu GB, Zhang HL, Zhou X, Tang L, Dong LW, Qin CJ, Huang S, Zhao LH, Zeng M, Wu MC, Yan HX (co-corresponding author), Wang HY. Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients. Hepatology.2016 Apr;63(4):1272-86. （15）

8.Yu LX, Yan L, Yang W, Wu FQ, Ling Y, Chen SZ, Cao D, Tan YX,Yan HX (co-corresponding author) and Wang HY. Platelets promote tumor metastasis via interaction between TLR4 and tumor cell-released high-mobility group box1 protein Nature Communication 2014 Oct 28;5:5256. doi: 10.1038/ncomms6256. IF: 11.9

9.Yan HX (corresponding author), Wu HP, Zhang HL, Ashton C, Tong C, Wu H, Qian QJ, Wang HY, Ying QL. p53 promotes inflammation-associated hepatocarcinogenesis by inducing HMGB1 release. J Hepatol.2013 Oct;59(4):762-8.. [Epub ahead of print] IF：18.9.

10.Yan HX (co-corresponding author), Wu HP, Zhang HL, Ashton C, Tong C, Wu J, Qian QJ, Wang HY, Ying QL. DNA damage-induced sustained p53 activation contributes to inflammation-associated hepatocarcinogenesis in rats. 2012 Oncogene. 2013 Sep 19;32(38):4565-71. IF: 6.6

11.Yan HX, Wu HP, Ashton C, Tong C, Ying QL. Rats deficient for p53 are susceptible to spontaneous and carcinogen-induced tumorigenesis. Carcinogenesis.2012 Oct;33(10):2001-5.Epub 2012 Jun 19. (2014 IF: 4)

12.Zhang HL, Yu LX, Yang W, Tang L, Lin Y, Tan YX, Shan L, Liu Q, Chen HY, Dai RY, He YQ, Wang C, Zheng LY, Li YQ, Wu FQ, Li Z, Yan HX (co-corresponding author), Wang HY. Profound impact of gut homeostasis on chemically induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats. 2012 J. Hepatology.J Hepatol. 2012 Oct;57(4):803-12. IF: 18.9)

13.Lin Y, Yu LX, Yan HX (joint first author), Yang W, Tang L, Zhang HL, Liu Q, Zhou SS, He YQ, Wang C, Wu MC and Wang HY. Gut-derived Lipopolysaccharide Promotes T Cell-mediated Hepatitis in Mice through Toll-like Receptor 4. 2012 Cancer Prev. Res.Cancer Prev Res (Phila). 2012 Sep;5(9):1090-102. Epub 2012 May 22. IF: 3.9

14.Yu LX, Yan HX (joint first author), Liu Q, Yang W, Wu HP, Dong W, Tang L, Lin Y, He YQ, Zou SS, Wang C, Zhang HL, Cao GW, Wu MC, Wang HY. Endotoxin Accumulation Prevents Carcinogen-Induced Apoptosis and Promotes Liver Tumorigenesis. Hepatology. 2010 Oct;52(4):1322-33. IF: 15

15.Liu Q, Zhai B, Yang W, Yu LX, Dong W, He YQ, Chen L, Tang L, Lin Y, Huang DD, Wu HP, Wu MC, Yan HX (co-corresponding author), Wang HY. Abrogation of Local Cancer Recurrence after Radiofrequency Ablation by Dendritic Cell-based Hyperthermic Tumor Vaccine. Mol. Ther.2009 Dec;17(12):2049-57. IF: 8.4

16.Yang W, Yan HX (joint first author), Chen L, Liu Q, He YQ, Yu LX, Zhang SH, Shan YF, Huang DD, Tang L, Kong XN, Chen C, Liu SQ, Wu MC and Wang HY. Wnt/β-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells. Cancer Res. 2008 Jun;68(11):4287-95. IF: 8.4

17.Kong XN, Yan HX(joint first author), Chen L, Dong LW, Yang W, Liu Q, Yu LX, Huang DD, Liu SQ, Liu H, Wu MC, Wang HY. LPS-Induced Down-regulation of Signal Regulatory Protein α Contributes to Innate Immune Activation in Macrophages. J. Exp. Med.2007 Oct 29; 204(11): 2719-2731. IF: 10.9

18.Chen L, Yan HX (joint first author), Chen J, Yang W, Zhai B, Liu Q, Cao HF, Liu SQ, Wu MC and Wang HY. Negative Regulation of c-Myc Transcription by Pancreas Duodenum Homeobox-1. Endocrinology2007 May;148(5):2168–2180. IF: 4.459

19.Yan HX, Yang W, Zhang R, Chen L, Tang L, Liu Q, Zai B, Liu SQ, Cao HF, Wu HP, Wu MC, Wang HY. Protein tyrosine phosphatase PCP-2 inhibits β-catenin signaling and increases E-cadherin-dependent cell adhesion. J. Biol. Chem.2006 Jun;281(22):15423–15433. IF: 4.1

20.Yan HX, Wang HY, Zhang R, Chen L, Li BA, Liu SQ, Cao HF, Qiu XH, Shan YF, Yan ZH, Wu HP, Tan YX, Wu MC. Negative regulation of hepatocellular carcinoma cell growth by signal regulatory protein alpha1. Hepatology. 2004 Sep;40(3):618-28. IF: 15

21.Yan HX, He YQ, Dong H, Zhang P, Zeng JZ, Cao HF, Wu MC, Wang HY. Physical and functional interaction between receptor-like protein tyrosine phosphatase PCP-2 and β-catenin. Biochemistry. 2002 Dec 31;41(52):15854-60. IF: 3.0